HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients
المؤلفون المشاركون
Kazemi, Kurosh
Geramizadeh, Bita
Aghdaie, Mahdokht H.
Darai, Masumeh
Azarpira, Negar
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
HLA-G molecules exhibit immunomodulatory properties that can delay graft rejection.
The 14 bp insertion/deletion polymorphism (INDEL) (rs16375) influences the stability of final HLA-G mRNA and its soluble isoforms.
Objective.
The present study aimed to investigate the possible association between this polymorphism and the incidence of acute rejection in Iranian liver transplant recipients.
Methods.
Different genotypes were evaluated by PCR.
The patients who had acute rejection within 6 months after transplantation were classified as acute rejection (AR) group, while others were considered as nonacute rejection (NAR) group.
Results.
Among the recipients, 21 patients (21%) had at least one episode of AR, while the other 79 patients (79%) had normal liver function.
No significant differences were found between the two groups regarding sex, MELD score, and primary liver disease.
Also, no difference was observed concerning rs16375 genotype and allele frequency (P=0.44, OR: 0.69; CI: 0.21–2.10).
Conclusion.
The study results revealed no significant difference between the AR and the NAR groups regarding the 14 bp INDEL genotypes and alleles.
Further studies are recommended to be conducted on other polymorphic sites as well as monitoring of serum HLA-G concentration in order to ascertain the potential implications of this marker in our population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azarpira, Negar& Aghdaie, Mahdokht H.& Kazemi, Kurosh& Geramizadeh, Bita& Darai, Masumeh. 2014. HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-500187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azarpira, Negar…[et al.]. HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-500187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azarpira, Negar& Aghdaie, Mahdokht H.& Kazemi, Kurosh& Geramizadeh, Bita& Darai, Masumeh. HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-500187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر