Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis
المؤلفون المشاركون
Srivastava, Rajni
Aggarwal, Amita
Dhir, Varun
المصدر
International Journal of Rheumatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-01
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Bone loss in ankylosing spondylitis may be related to inflammation.
Data from previous studies on circulating levels of sRANKL, OPG, MMP3, and TIMP is inconsistent; thus this study is planned to look at this aspect in Asian Indian patients.
Methods.
Cross-sectional study included patients with ankylosing spondylitis and age- and gender-similar controls.
Serum levels of sRANKL, OPG, MMP-3, and TIMP-1 were measured by ELISA.
Results.
Included 85 patients (M : F = 82 : 3) having mean age (±SD) 33.0±10.0 years and disease duration 11.3±7.3 years.
BASDAI, BASFI, BASMI, and ESR were 4.0±2.2, 3.9±2.8, 3.0±2.8, and 59.2±31.2, respectively.
Patients had higher mean (±SD) OPG level (649.7±286.8, 389.3±244.8 pg/mL, P<0.001).
However, there was no difference in sRANKL (349.2±872.0, 554.7±1850.1, P=ns).
Serum MMP-3 (91.4±84.7, 55.9±37.1 ng/mL, P<0.01) and TIMP-1 (520.6±450.7, 296.5±114.2 ng/mL, P<0.001) levels were higher in patients; however, there was no difference in MMP-3/TIMP-1 ratio.
Conclusion.
Circulating levels of OPG were higher; however, there was no difference in sRANKL in Asian Indian ankylosing spondylitis patients.
Although both MMP-3 and TIMP-1 were raised, their ratio was not different from that of controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dhir, Varun& Srivastava, Rajni& Aggarwal, Amita. 2013. Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500201
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dhir, Varun…[et al.]. Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis. International Journal of Rheumatology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-500201
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dhir, Varun& Srivastava, Rajni& Aggarwal, Amita. Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500201
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500201
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر