![](/images/graphics-bg.png)
Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis
المؤلفون المشاركون
Srivastava, Rajni
Aggarwal, Amita
Dhir, Varun
المصدر
International Journal of Rheumatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-01
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Bone loss in ankylosing spondylitis may be related to inflammation.
Data from previous studies on circulating levels of sRANKL, OPG, MMP3, and TIMP is inconsistent; thus this study is planned to look at this aspect in Asian Indian patients.
Methods.
Cross-sectional study included patients with ankylosing spondylitis and age- and gender-similar controls.
Serum levels of sRANKL, OPG, MMP-3, and TIMP-1 were measured by ELISA.
Results.
Included 85 patients (M : F = 82 : 3) having mean age (±SD) 33.0±10.0 years and disease duration 11.3±7.3 years.
BASDAI, BASFI, BASMI, and ESR were 4.0±2.2, 3.9±2.8, 3.0±2.8, and 59.2±31.2, respectively.
Patients had higher mean (±SD) OPG level (649.7±286.8, 389.3±244.8 pg/mL, P<0.001).
However, there was no difference in sRANKL (349.2±872.0, 554.7±1850.1, P=ns).
Serum MMP-3 (91.4±84.7, 55.9±37.1 ng/mL, P<0.01) and TIMP-1 (520.6±450.7, 296.5±114.2 ng/mL, P<0.001) levels were higher in patients; however, there was no difference in MMP-3/TIMP-1 ratio.
Conclusion.
Circulating levels of OPG were higher; however, there was no difference in sRANKL in Asian Indian ankylosing spondylitis patients.
Although both MMP-3 and TIMP-1 were raised, their ratio was not different from that of controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dhir, Varun& Srivastava, Rajni& Aggarwal, Amita. 2013. Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500201
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dhir, Varun…[et al.]. Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis. International Journal of Rheumatology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-500201
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dhir, Varun& Srivastava, Rajni& Aggarwal, Amita. Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500201
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500201
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)