Effect of S-PRG Eluate on Biofilm Formation and Enzyme Activity of Oral Bacteria

الملخص EN

Recently, the antibacterial activity of a composite resin containing prereacted glass ionomer (S-PRG) filler was revealed.

We examined the effect of an S-PRG eluate on various biologic activities of Streptococcus mutans and Porphyromonas gingivalis.

Adherence ability of S.

mutans was evaluated by microtiter plate assay; protease and gelatinase activities of P.

gingivalis were examined by synthetic substrate hydrolysis and gelatin film spot assay, respectively.

Coaggregation of P.

gingivalis with Fusobacterium nucleatum was also examined.

S-PRG eluate was found to suppress streptococcal adherence.

S-PRG eluate inhibited the protease and gelatinase activities of P.

gingivalis and the coaggregation between P.

gingivalis and F.

nucleatum.

These results indicate that S-PRG eluate suppresses streptococcal adherence and inhibits the protease and coaggregation activities of P.

gingivalis.

These findings may prompt research into novel strategies for preventing caries and periodontitis.