A Genome-Wide Identification of Genes Undergoing Recombination and Positive Selection in Neisseria

المؤلفون المشاركون

Liang, Long
Yue, Junjie
Yin, Zhiqiu
Ren, Hongguang
Jin, Yuan
Yu, Dong
Zhou, Wei

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-10

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Currently, there is particular interest in the molecular mechanisms of adaptive evolution in bacteria.

Neisseria is a genus of gram negative bacteria, and there has recently been considerable focus on its two human pathogenic species N.

meningitidis and N.

gonorrhoeae.

Until now, no genome-wide studies have attempted to scan for the genes related to adaptive evolution.

For this reason, we selected 18 Neisseria genomes (14 N.

meningitidis, 3 N.

gonorrhoeae and 1 commensal N.

lactamics) to conduct a comparative genome analysis to obtain a comprehensive understanding of the roles of natural selection and homologous recombination throughout the history of adaptive evolution.

Among the 1012 core orthologous genes, we identified 635 genes with recombination signals and 10 genes that showed significant evidence of positive selection.

Further functional analyses revealed that no functional bias was found in the recombined genes.

Positively selected genes are prone to DNA processing and iron uptake, which are essential for the fundamental life cycle.

Overall, the results indicate that both recombination and positive selection play crucial roles in the adaptive evolution of Neisseria genomes.

The positively selected genes and the corresponding amino acid sites provide us with valuable targets for further research into the detailed mechanisms of adaptive evolution in Neisseria.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yu, Dong& Jin, Yuan& Yin, Zhiqiu& Ren, Hongguang& Zhou, Wei& Liang, Long…[et al.]. 2014. A Genome-Wide Identification of Genes Undergoing Recombination and Positive Selection in Neisseria. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500326

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yu, Dong…[et al.]. A Genome-Wide Identification of Genes Undergoing Recombination and Positive Selection in Neisseria. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-500326

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yu, Dong& Jin, Yuan& Yin, Zhiqiu& Ren, Hongguang& Zhou, Wei& Liang, Long…[et al.]. A Genome-Wide Identification of Genes Undergoing Recombination and Positive Selection in Neisseria. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500326

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-500326