Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment
المؤلفون المشاركون
Huang, Zhongdong
Zimmerman, Susan
Symons, Rebecca
Jiang, Ping
Jacobetz, Michael A.
Osgood, Ryan J.
Singha, Netai C.
Thompson, Curtis B.
Zhao, Chunmei
Kultti, Anne
Infante, Jeffrey R.
Frost, Gregory I.
Tuveson, David A.
Li, Xiaoming
Shepard, H. Michael
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-24
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer.
The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated in pancreatic cancer growth and the tumor microenvironment.
Overexpression of HAS3 increased hyaluronan synthesis in BxPC-3 pancreatic cancer cells.
In vivo, overexpression of HAS3 led to faster growing xenograft tumors with abundant extracellular hyaluronan accumulation.
Treatment with pegylated human recombinant hyaluronidase (PEGPH20) removed extracellular hyaluronan and dramatically decreased the growth rate of BxPC-3 HAS3 tumors compared to parental tumors.
PEGPH20 had a weaker effect on HAS2-overexpressing tumors which grew more slowly and contained both extracellular and intracellular hyaluronan.
Accumulation of hyaluronan was associated with loss of plasma membrane E-cadherin and accumulation of cytoplasmic β-catenin, suggesting disruption of adherens junctions.
PEGPH20 decreased the amount of nuclear hypoxia-related proteins and induced translocation of E-cadherin and β-catenin to the plasma membrane.
Translocation of E-cadherin was also seen in tumors from a transgenic mouse model of pancreatic cancer and in a human non-small cell lung cancer sample from a patient treated with PEGPH20.
In conclusion, hyaluronan accumulation by HAS3 favors pancreatic cancer growth, at least in part by decreasing epithelial cell adhesion, and PEGPH20 inhibits these changes and suppresses tumor growth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kultti, Anne& Zhao, Chunmei& Singha, Netai C.& Zimmerman, Susan& Osgood, Ryan J.& Symons, Rebecca…[et al.]. 2014. Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-500515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kultti, Anne…[et al.]. Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-500515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kultti, Anne& Zhao, Chunmei& Singha, Netai C.& Zimmerman, Susan& Osgood, Ryan J.& Symons, Rebecca…[et al.]. Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-500515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر