Influence of Immune Responses in GeneStem Cell Therapies for Muscular Dystrophies

الملخص EN

Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes.

Inflammation and innate or adaptive immune response activation are prominent features of MDs.

Various therapies under development are directed toward rescuing the dystrophic muscle damage using gene transfer or cell therapy.

Here we discussed current knowledge about involvement of immune system responses to experimental therapies in MDs.