Treatment of Aggressive NK-Cell Leukemia : A Case Report and Review of the Literature

الملخص EN

Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells.

It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months.

The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients.

We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy.

We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia.