A Preliminary Study on the Relationship between Platelet Serotonin Transporter Functionality, Depression, and Fatigue in Patients with Untreated Chronic Hepatitis C
المؤلفون المشاركون
Schäfer, Martin
Schlosser, Beate
Therstappen, Eric
Uebelhack, Ralf
Biermer, Michael
Arck, Petra
Franke, Leonora
Berg, Thomas
Friebe, Astrid
المصدر
Depression Research and Treatment
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective and Methods.
Although the interaction between fatigue and depression in patients with chronic hepatitis C infection (HCV) has been recognized, the biological correlates of this observation have yet to be reported.
We addressed this issue by examining serotonin transporter- (SERT-) driven [14C]-serotonin uptake rate (SUR) and serotonin content in platelets of 65 untreated HCV patients and 65 healthy control subjects (HCS).
All patients completed report questionnaires for fatigue, depression, and general psychopathology.
Structured interviews were conducted by a board-certified psychiatrist.
Results.
Whereas 36 of the patients experienced fatigue of moderate-to-severe intensity, only 16 reported symptoms of depression (BDI score > 10).
Mean SUR in patients with depressive symptoms was significantly higher relative to the HCS, corresponding to a large Cohen’s effect size of d=1.45 (95% CI=0.66—1.83).
Patients who rated their fatigue to have a marked impact on mood and activity displayed a moderate relationship between the BDI score and SUR (n=18, r=0.563, P=0.015), which becomes stronger after controlling for age, gender, and thrombocytopenia (rpart=0.710, P=0.003).
In the univariate analysis, high fatigue interference score, thrombocytopenia, and high SUR were all significant predictors of depression.
Conclusions.
High SERT activity could be implicated in the expression of depressive symptoms especially in a subgroup of HCV patients who are feeling fatigue as markedly distressing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Franke, Leonora& Therstappen, Eric& Schlosser, Beate& Biermer, Michael& Berg, Thomas& Schäfer, Martin…[et al.]. 2014. A Preliminary Study on the Relationship between Platelet Serotonin Transporter Functionality, Depression, and Fatigue in Patients with Untreated Chronic Hepatitis C. Depression Research and Treatment،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-500834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Franke, Leonora…[et al.]. A Preliminary Study on the Relationship between Platelet Serotonin Transporter Functionality, Depression, and Fatigue in Patients with Untreated Chronic Hepatitis C. Depression Research and Treatment No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-500834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Franke, Leonora& Therstappen, Eric& Schlosser, Beate& Biermer, Michael& Berg, Thomas& Schäfer, Martin…[et al.]. A Preliminary Study on the Relationship between Platelet Serotonin Transporter Functionality, Depression, and Fatigue in Patients with Untreated Chronic Hepatitis C. Depression Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-500834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر