Discrepancy between mRNA and Protein Expression of Neutrophil Gelatinase-Associated Lipocalin in Bronchial Epithelium Induced by Sulfur Mustard
المؤلفون المشاركون
Ghanei, Mostafa
Imani Fooladi, Abbas Ali
Nourani, Mohammad Reza
Halabian, Raheleh
Roudkenar, Mehryar Habibi
Ebrahimi, Majid
Kondo, Hisatake
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Sulfur mustard (SM) is a potent vesicant that has been employed as a chemical weapon in various conflicts during the 20th century.
More recently, mustard was used in the Iraq conflict against Iranian troops and civilians.
At the present time there are more than 40.000 people suffering from pulmonary lesions special bronchiolitis obliterans (BOs) due to mustard gas.
SM increases the endogenous production of reactive oxygen species (ROS).
Neutrophil Gelatinase-associated Lipocalin 2 (Lcn2, NGAL) is a member of the lipocalin superfamily for which a variety of functions such as cellular protection against oxidative stress have been reported.
Ten normal and Twenty SM-induced COPD patient individuals were studied.
Assessment of NGAL expressions in healthy and the patients endobrinchial biopsies were performed by semiquantitative RT-PCR, real-time RT-PCR, and Immunohistochemistry analysis.
While Normal control samples expressed same level of mRNA NGAL, expression level of mRNA-NGAL was upregulated about 1.4- to 9.8-folds compared to normal samples.
No significant immunoreactivity was revealed in both samples.
As we are aware this is the first report of induction of NGAL in patients exposed to SM.
NGAL may play an important role in cellular protection against oxidative stress toxicity induced by mustard gas in airway wall of patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ebrahimi, Majid& Roudkenar, Mehryar Habibi& Imani Fooladi, Abbas Ali& Halabian, Raheleh& Ghanei, Mostafa& Kondo, Hisatake…[et al.]. 2010. Discrepancy between mRNA and Protein Expression of Neutrophil Gelatinase-Associated Lipocalin in Bronchial Epithelium Induced by Sulfur Mustard. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500923
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ebrahimi, Majid…[et al.]. Discrepancy between mRNA and Protein Expression of Neutrophil Gelatinase-Associated Lipocalin in Bronchial Epithelium Induced by Sulfur Mustard. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-500923
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ebrahimi, Majid& Roudkenar, Mehryar Habibi& Imani Fooladi, Abbas Ali& Halabian, Raheleh& Ghanei, Mostafa& Kondo, Hisatake…[et al.]. Discrepancy between mRNA and Protein Expression of Neutrophil Gelatinase-Associated Lipocalin in Bronchial Epithelium Induced by Sulfur Mustard. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500923
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500923
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر