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The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions
المؤلفون المشاركون
Kim, Sun-A
Ko, Seong-Gyu
Kim, In Sook
Yoo, Hye Hyun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-07
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
In the present study, the effect of CP-001, a standardized herbal mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus, on cytochrome P450 (CYP) enzyme-mediated drug metabolism was investigated in vitro to evaluate the potential for herb-drug interactions.
CP-001 was tested at concentrations of 1, 3, 10, 30, and 100 μg/mL.
A CYP-specific substrate mixture was incubated with CP-001 in human liver microsomes, and the metabolites generated by each CYP-specific metabolic reaction were measured by liquid chromatography-tandem mass spectrometry.
CP-001 seemed to slightly inhibit some CYP isozymes, but the IC50 values for all CYP isozymes were greater than 100 μg/mL.
Furthermore, CP-001 did not exhibit time-dependent CYP inhibitory activities, indicating that it does not act as a mechanism-based inactivator of CYP enzymes.
In conclusion, the effects of CP-001 on CYP isozyme activities were negligible at the concentrations tested.
Therefore, the likelihood of herbal mixture-drug interaction is considered minimal.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yoo, Hye Hyun& Kim, Sun-A& Kim, In Sook& Ko, Seong-Gyu. 2013. The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-501044
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yoo, Hye Hyun…[et al.]. The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-501044
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yoo, Hye Hyun& Kim, Sun-A& Kim, In Sook& Ko, Seong-Gyu. The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-501044
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501044
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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