![](/images/graphics-bg.png)
Assessment of Anti-Cytogenotoxic Effects of Quercetin in Animals Treated with Topotecan
المؤلف
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
The present investigation was directed to study the possible chemoprotective activity of orally administered quercetin against topotecan-induced cyto- and genotoxicity towards mouse somatic cells in vivo.
DNA strand breaks, micronuclei formation, and mitotic activity were undertaken in the current study as markers of cyto- and genotoxicity.
Oxidative stress markers such as intracellular reactive oxygen species generation, lipid peroxidation, and reduced and oxidized glutathione were assessed in bone marrow as a possible mechanism underlying this amelioration.
Quercetin was neither cytotoxic nor genotoxic in mice at doses tested.
Pretreatment of mice with quercetin significantly reduced topotecan-induced genotoxicity and cytotoxicity in bone marrow cells, and these effects were dose dependent.
Moreover, prior administration of quercetin ahead of topotecan challenge ameliorated oxidative stress markers.
In conclusion, quercetin has a protective role in the abatement of topotecan-induced cyto- and genotoxicity in the bone marrow cells of mice that resides, at least in part, on its antioxidant effects.
Based on the data presented, strategies can be developed to decrease the topotecan-induced bone marrow suppression and secondary malignancy in cancer patients and medical personnel exposing to topotecan.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bakheet, Saleh A.. 2011. Assessment of Anti-Cytogenotoxic Effects of Quercetin in Animals Treated with Topotecan. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-501066
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bakheet, Saleh A.. Assessment of Anti-Cytogenotoxic Effects of Quercetin in Animals Treated with Topotecan. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-501066
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bakheet, Saleh A.. Assessment of Anti-Cytogenotoxic Effects of Quercetin in Animals Treated with Topotecan. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-501066
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501066
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)