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Promise and Challenge : The Lens Model as a Biomarker for Early Diagnosis of Alzheimer's Disease
المؤلفون المشاركون
Li, Zhaoming
Jia, Yanjie
Tian, Tian
Zhang, Boai
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is the most common form of dementia pathologically characterized by cerebral amyloid-beta (Aβ) deposition.
Early and accurate diagnosis of the disease still remains a big challenge.
There is evidence that Aβ aggregation starts to occur years before symptoms arise.
Noninvasive monitoring of Aβ plaques is critical for both the early diagnosis and prognosis of AD.
Presently, there is a major effort on looking for a reasonably priced technology capable of diagnosing AD by detecting the presence of Aβ.
Studies suggest that AD is systemic rather than brain-limited focus diseases and the aggregation of the disease-causing proteins also takes place in lens except the brain.
There is a possible relationship between AD and a specific subtype of age-related cataract (supranuclear cataract).
If similar abnormal protein deposits are present in the lens, it would facilitate non-invasive diagnosis and monitoring of disease progression.
However, there are controversies on the issues related to performance and validation of Aβ deposition in lens as biomarkers for early detection of AD.
Here we review the recent findings concerning Aβ deposition in the lenses of AD patients and evaluate if the ocular lens can provide a biomarker for AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Tian& Zhang, Boai& Jia, Yanjie& Li, Zhaoming. 2014. Promise and Challenge : The Lens Model as a Biomarker for Early Diagnosis of Alzheimer's Disease. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-501237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Tian…[et al.]. Promise and Challenge : The Lens Model as a Biomarker for Early Diagnosis of Alzheimer's Disease. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-501237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Tian& Zhang, Boai& Jia, Yanjie& Li, Zhaoming. Promise and Challenge : The Lens Model as a Biomarker for Early Diagnosis of Alzheimer's Disease. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-501237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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