Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells
المؤلفون المشاركون
Lin, En-Shyh
Hung, Jen-Yu
Wen, Ching-Wen
Chen, Chung-Yi
Kuo, Po-Lin
Hsu, Ya-Ling
Huang, Ming-Shyan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-24
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
This study investigated the anticancer effects of subamolide A (Sub-A), isolated from Cinnamomum subavenium, on human nonsmall cell lung cancer cell lines A549 and NCI-H460.
Treatment of cancer cells with Sub-A resulted in decreased cell viability of both lung cancer cell lines.
Sub-A induced lung cancer cell death by triggering mitotic catastrophe with apoptosis.
It triggered oxidant stress, indicated by increased cellular reactive oxygen species (ROS) production and decreased glutathione level.
The elevated ROS triggered the activation of ataxia-telangiectasia mutation (ATM), which further enhanced the ATF3 upregulation and subsequently enhanced p53 function by phosphorylation at Serine 15 and Serine 392.
The antioxidant, EUK8, significantly decreased mitotic catastrophe by inhibiting ATM activation, ATF3 expression, and p53 phosphorylation.
The reduction of ATM and ATF3 expression by shRNA decreased Sub-A-mediated p53 phosphorylation and mitotic catastrophe.
Sub-A also caused a dramatic 70% reduction in tumor size in an animal model.
Taken together, cell death of lung cancer cells in response to Sub-A is dependent on ROS generation, which triggers mitotic catastrophe followed by apoptosis.
Therefore, Sub-A may be a novel anticancer agent for the treatment of nonsmall cell lung cancer.Erratum to “Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells”dx.doi.org/10.1155/2013/687142
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hung, Jen-Yu& Wen, Ching-Wen& Hsu, Ya-Ling& Lin, En-Shyh& Huang, Ming-Shyan& Chen, Chung-Yi…[et al.]. 2013. Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-501397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hung, Jen-Yu…[et al.]. Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-501397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hung, Jen-Yu& Wen, Ching-Wen& Hsu, Ya-Ling& Lin, En-Shyh& Huang, Ming-Shyan& Chen, Chung-Yi…[et al.]. Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-501397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر