Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs

الملخص EN

The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia.

The dogs (n=10) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's lactate solution and hydroxyethyl starch-based solution in a 2 : 1 ratio.

The cardiac output was measured by Doppler echocardiography and blood pressure by oscillometric device, and posteriorly hemodynamic parameters were calculated.

The anemic groups had increase in cardiac index (P<.05) (3.82±1.05 to 5.86±1.49 and 5.81±1.63 L/min × m2) and decreases (P<.05) in the indices of total peripheral resistance (6797.81±3060.22 to 3220.14±1275.02 and 3887.74±1394.89 dina⋅seg/cm5 × m2) and oxygen delivery (7942.84±3344.00 to 4021.68±1627.00 and 4430.82±1402.61 mL/min × m2), respectively.

There were no significant changes in pH, but PaO2 and SaO2 values were increased, and PaCO2 reduced in anemic dogs (P<.05).

Therefore, acute normovolemic anemia can create significant hemodynamic changes and despite some hemogasometric changes, there were no changes in the acid-base status in dogs.