Sumoylation of Human Translationally Controlled Tumor Protein Is Important for Its Nuclear Transport
المؤلفون المشاركون
Munirathinam, Gnanasekar
Kalyanasundaram, Ramaswamy
المصدر
Biochemistry Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Translationally controlled tumor protein (TCTP) lacks nuclear bipartite localization signal sequence; yet TCTP is present abundantly in the nucleus.
At present it is not known how TCTP gets transported to the nucleus.
Sequence analyses showed that all TCTPs described to date have putative small ubiquitin-like modifier (SUMO) motifs.
Since SUMO modification plays an important role in the nuclear transport of proteins, we evaluated whether SUMO motifs are important for transport of TCTP into the nucleus.
We show that TCTP exists in sumoylated form in cytoplasm and nucleus of mammalian cells.
Point mutation of lysine residue in the SUMO motif compromised the ability of TCTP to get sumoylated in vitro.
When cells were transfected with FLAG-tagged mutated TCTP, nuclear transport of TCTP was inhibited confirming that sumoylation is critical for the nuclear transport of TCTP.
Our previous studies demonstrated that TCTP can function as an antioxidant protein in the nucleus.
When we mutated TCTP at the SUMO motif the antioxidant function of TCTP was compromised.
Results presented in this study thus show that sumoylation plays an important role in the transport of TCTP into the nucleus where they function as antioxidant protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Munirathinam, Gnanasekar& Kalyanasundaram, Ramaswamy. 2012. Sumoylation of Human Translationally Controlled Tumor Protein Is Important for Its Nuclear Transport. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501709
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Munirathinam, Gnanasekar& Kalyanasundaram, Ramaswamy. Sumoylation of Human Translationally Controlled Tumor Protein Is Important for Its Nuclear Transport. Biochemistry Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-501709
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Munirathinam, Gnanasekar& Kalyanasundaram, Ramaswamy. Sumoylation of Human Translationally Controlled Tumor Protein Is Important for Its Nuclear Transport. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501709
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501709
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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