Genetics of Late-Onset Alzheimer's Disease : Update from the Alzgene Database and Analysis of Shared Pathways
المؤلفون المشاركون
Politis, Antonis M.
De Ronchi, Diana
Serretti, Alessandro
Papadimitriou, George N.
Olgiati, Paolo
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The genetics of late-onset Alzheimer's disease (LOAD) has taken impressive steps forwards in the last few years.
To date, more than six-hundred genes have been linked to the disorder.
However, only a minority of them are supported by a sufficient level of evidence.
This review focused on such genes and analyzed shared biological pathways.
Genetic markers were selected from a web-based collection (Alzgene).
For each SNP in the database, it was possible to perform a meta-analysis.
The quality of studies was assessed using criteria such as size of research samples, heterogeneity across studies, and protection from publication bias.
This produced a list of 15 top-rated genes: APOE, CLU, PICALM, EXOC3L2, BIN1, CR1, SORL1, TNK1, IL8, LDLR, CST3, CHRNB2, SORCS1, TNF, and CCR2.
A systematic analysis of gene ontology terms associated with each marker showed that most genes were implicated in cholesterol metabolism, intracellular transport of beta-amyloid precursor, and autophagy of damaged organelles.
Moreover, the impact of these genes on complement cascade and cytokine production highlights the role of inflammatory response in AD pathogenesis.
Gene-gene and gene-environment interactions are prominent issues in AD genetics, but they are not specifically featured in the Alzgene database.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olgiati, Paolo& Politis, Antonis M.& Papadimitriou, George N.& De Ronchi, Diana& Serretti, Alessandro. 2011. Genetics of Late-Onset Alzheimer's Disease : Update from the Alzgene Database and Analysis of Shared Pathways. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-501742
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olgiati, Paolo…[et al.]. Genetics of Late-Onset Alzheimer's Disease : Update from the Alzgene Database and Analysis of Shared Pathways. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-501742
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olgiati, Paolo& Politis, Antonis M.& Papadimitriou, George N.& De Ronchi, Diana& Serretti, Alessandro. Genetics of Late-Onset Alzheimer's Disease : Update from the Alzgene Database and Analysis of Shared Pathways. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-501742
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501742
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر