Radical Prostatectomy as a First-Line Treatment in Patients with Initial PSA >20 ngmL

المؤلفون المشاركون

Hadjiev, Vesselin I.
Hinev, Alexander I.
Anakievski, Deyan

المصدر

International Journal of Surgical Oncology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-07-19

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Initial PSA >20 ng/mL is generally considered an adverse prognostic feature in prostate cancer (PCa).

Our goals were to estimate the impact of radical prostatectomy (RP) on biochemical recurrence- (BCR-) free and cancer-specific survival (CSS) rates of PCa patients with PSA >20 ng/mL, and to identify patients with favorable oncological outcome.

Using 20 ng/mL as a cut-point value, 205 PCa patients, who underwent RP, were stratified into two groups.

Multivariate analysis was used to determine the significant outcome predictors among patients with PSA >20 ng/mL.

Men in this group had significantly lower 10-yr BCR-free and CSS rates than patients with PSA ≤20 ng/mL (20.7% versus 79.6% (P<0.001) and 65.0% versus 87.9% (P=0.010), resp.).

Pathological stage and lymph node status were found to be the only independent predictors of PSA failure.

Patients with favorable combination of these variables (pT2, N0) had significantly longer 10-yr BCR-free and CSS rates (44.3% versus 0% (P=0.001) and 100.0% versus 33.6% (P=0.011), resp.).

High PSA values do not uniformly indicate poor prognosis after surgery.

Patients, who might benefit the most from RP, are those with organ confined PCa and negative lymph nodes.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hinev, Alexander I.& Anakievski, Deyan& Hadjiev, Vesselin I.. 2012. Radical Prostatectomy as a First-Line Treatment in Patients with Initial PSA >20 ngmL. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-501797

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hinev, Alexander I.…[et al.]. Radical Prostatectomy as a First-Line Treatment in Patients with Initial PSA >20 ngmL. International Journal of Surgical Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-501797

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hinev, Alexander I.& Anakievski, Deyan& Hadjiev, Vesselin I.. Radical Prostatectomy as a First-Line Treatment in Patients with Initial PSA >20 ngmL. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-501797

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-501797