![](/images/graphics-bg.png)
Stanniocalcin-1 Co-Localizes with Insulin in the Pancreatic Islets
المؤلفون المشاركون
Turner, Jeffrey K.
Zaidi, Deenaz
Durst, Michelle A.
Wagner, Graham F.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The polypeptide hormone stanniocalcin-1 (STC-1) is widely expressed in mammals and signals both locally and systemically.
In many tissues STC-1 ligand is sequestered by target cell organelles (mitochondria, nuclei, and cholesterol lipid droplets) to exert diverse biological effects.
Most notably, STC-1 serves as an uncoupler of oxidative phosphorylation in liver, muscle, and kidney mitochondria.
The present paper describes the identification of STC-1 receptors in mouse pancreatic β cells and the discovery that the ligand co-localizes with insulin in pancreatic β cells.
In situ hybridization (ISH) analysis subsequently revealed that pancreatic β cells were the source of the ligand.
Intriguingly however, all ISH signal was localized over putative islet cell nuclei as opposed to the cell cytoplasm.
Real-time qPCR and agarose gel electrophoresis revealed that the STC-1 amplicon generated from islet cell total RNA was the same size as that from kidney.
However, relative levels of STC-1 gene expression were >100-fold lower in islets than those in kidney tissue.
Collectively, these findings are indicative of a local STC-1 signalling pathway in pancreatic β cells.
The role of STC-1 in this context remains to be established, but it could very well entail the regulation of β cell mitochondria membrane potential which is an integral aspect of regulated insulin release.
Interestingly, STC-1 immunoreactivity was not evident in embryonic pancreatic islets, suggesting that ligand synthesis may only commence postnatally.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaidi, Deenaz& Turner, Jeffrey K.& Durst, Michelle A.& Wagner, Graham F.. 2012. Stanniocalcin-1 Co-Localizes with Insulin in the Pancreatic Islets. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501839
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaidi, Deenaz…[et al.]. Stanniocalcin-1 Co-Localizes with Insulin in the Pancreatic Islets. ISRN Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-501839
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaidi, Deenaz& Turner, Jeffrey K.& Durst, Michelle A.& Wagner, Graham F.. Stanniocalcin-1 Co-Localizes with Insulin in the Pancreatic Islets. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501839
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501839
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)