In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH

المؤلفون المشاركون

Futakami, Masae
Kitamura, Koichiro
Yamamoto, Kenji
Nishigaki, Koichi
Suzuki, Miho
Biyani, Madhu
Kawakubo, Tomoyo

المصدر

International Journal of Peptides

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-03-22

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الكيمياء

الملخص EN

The aspartic protease cathepsin E has been shown to induce apoptosis in cancer cells under physiological conditions.

Therefore, cathepsin E-activity-enhancing peptides functioning in the physiological pH range are valuable potential cancer therapeutic candidates.

Here, we have used a general in vitro selection method (evolutionary rapid panning analysis system (eRAPANSY)), based on inverse substrate-function link (SF-link) selection to successfully identify cathepsin E-activity-enhancing peptide aptamers at neutral pH.

A successive enrichment of peptide activators was attained in the course of selection.

One such peptide activated cathepsin E up to 260%, had a high affinity (KD; ∼300 nM), and had physiological activity as demonstrated by its apoptosis-inducing reaction in cancerous cells.

This method is expected to be widely applicable for the identification of protease-activity-enhancing peptide aptamers.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Biyani, Madhu& Futakami, Masae& Kitamura, Koichiro& Kawakubo, Tomoyo& Suzuki, Miho& Yamamoto, Kenji…[et al.]. 2011. In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-501846

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Biyani, Madhu…[et al.]. In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH. International Journal of Peptides No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-501846

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Biyani, Madhu& Futakami, Masae& Kitamura, Koichiro& Kawakubo, Tomoyo& Suzuki, Miho& Yamamoto, Kenji…[et al.]. In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-501846

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-501846