Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts
المؤلفون المشاركون
Angeloni, Cristina
Hrelia, Silvana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Flavonoids possess several biological and pharmacological activities.
Quercetin (Q), a naturally occurring flavonoid, has been shown to downregulate inflammatory responses and provide cardioprotection.
However, the mechanisms behind the anti-inflammatory properties of Q in cardiac cells are poorly understood.
In inflammation, nitric oxide (NO) acts as a proinflammatory mediator and is synthesized by inducible nitric oxide synthase (iNOS) in response to pro-inflammatory agents such as lipopolysaccharide (LPS), a causative agent in myocardial depression during sepsis.
In the present study, we evaluated the protective effect of Q on rat cardiac dysfunction during sepsis induced by LPS.
Pretreatment of H9c2 cardiomyoblasts with Q inhibited LPS-induced iNOS expression and NO production and counteracted oxidative stress caused by the unregulated NO production that leads to the generation of peroxynitrite and other reactive nitrogen species.
In addition, Q pretreatment significantly counteracted apoptosis cell death as measured by immunoblotting of the cleaved caspase 3 and caspase 3 activity.
Q also inhibited the LPS-induced phosphorylation of the stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase that are involved in the inhibition of cell growth as well as the induction of apoptosis.
In conclusion, these results suggest that Q might serve as a valuable protective agent in cardiovascular inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Angeloni, Cristina& Hrelia, Silvana. 2012. Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502067
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Angeloni, Cristina& Hrelia, Silvana. Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502067
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Angeloni, Cristina& Hrelia, Silvana. Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502067
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502067
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر