CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma
المؤلفون المشاركون
Zhang, Wen-Feng
Ma, Si-Rui
Zhao, Zhi-Li
Huang, Cong-Fa
Wang, Yu-Fan
Zhao, Yi-Fang
Sun, Zhi-Jun
Zhang, Lu
Wang, Wei-Ming
He, Ke-Fei
Liu, Bing
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Tumor-associated macrophages (TAMs) play an important role in the progression and prognostication of numerous cancers.
However, the role and clinical significance of TAM markers in oral squamous cell carcinoma (OSCC) has not been elucidated.
The present study was designed to investigate the correlation between the expression of TAM markers and pathological features in OSCC by tissue microarray.
Tissue microarrays containing 16 normal oral mucosa, 6 oral epithelial dysplasia, and 43 OSCC specimens were studied by immunohistochemistry.
We observed that the protein expression of the TAM markers CD68 and CD163 as well as the cancer stem cell (CSC) markers ALDH1, CD44, and SOX2 increased successively from the normal oral mucosa to OSCC.
The expressions of CD68 and CD163 were significantly associated with lymph node status, and SOX2 was significantly correlated with pathological grade and lymph node status, whereas ALDH1 was correlated with tumor stage.
Furthermore, CD68 was significantly correlated with CD163, SOX2, and ALDH1 (P<0.05).
Kaplan-Meier analysis revealed that OSCC patients overexpressing CD163 had significantly worse overall survival (P<0.05).
TAM markers are associated with cancer stem cell marker and OSCC overall survival, suggesting their potential prognostic value in OSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Ke-Fei& Zhang, Lu& Huang, Cong-Fa& Ma, Si-Rui& Wang, Yu-Fan& Wang, Wei-Ming…[et al.]. 2014. CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502222
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Ke-Fei…[et al.]. CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-502222
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Ke-Fei& Zhang, Lu& Huang, Cong-Fa& Ma, Si-Rui& Wang, Yu-Fan& Wang, Wei-Ming…[et al.]. CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502222
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502222
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر