Identifying Hierarchical and Overlapping Protein Complexes Based on Essential Protein-Protein Interactions and “Seed-Expanding” Method
المؤلفون المشاركون
Zhou, Wei
Wang, Jianxin
Ren, Jun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Many evidences have demonstrated that protein complexes are overlapping and hierarchically organized in PPI networks.
Meanwhile, the large size of PPI network wants complex detection methods have low time complexity.
Up to now, few methods can identify overlapping and hierarchical protein complexes in a PPI network quickly.
In this paper, a novel method, called MCSE, is proposed based on λ-module and “seed-expanding.” First, it chooses seeds as essential PPIs or edges with high edge clustering values.
Then, it identifies protein complexes by expanding each seed to a λ-module.
MCSE is suitable for large PPI networks because of its low time complexity.
MCSE can identify overlapping protein complexes naturally because a protein can be visited by different seeds.
MCSE uses the parameter λ_th to control the range of seed expanding and can detect a hierarchical organization of protein complexes by tuning the value of λ_th.
Experimental results of S.
cerevisiae show that this hierarchical organization is similar to that of known complexes in MIPS database.
The experimental results also show that MCSE outperforms other previous competing algorithms, such as CPM, CMC, Core-Attachment, Dpclus, HC-PIN, MCL, and NFC, in terms of the functional enrichment and matching with known protein complexes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Jun& Zhou, Wei& Wang, Jianxin. 2014. Identifying Hierarchical and Overlapping Protein Complexes Based on Essential Protein-Protein Interactions and “Seed-Expanding” Method. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-502229
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Jun…[et al.]. Identifying Hierarchical and Overlapping Protein Complexes Based on Essential Protein-Protein Interactions and “Seed-Expanding” Method. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-502229
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Jun& Zhou, Wei& Wang, Jianxin. Identifying Hierarchical and Overlapping Protein Complexes Based on Essential Protein-Protein Interactions and “Seed-Expanding” Method. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-502229
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502229
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر