Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis
المؤلفون المشاركون
Seigo, Michaela
Saidha, Shiv
Harrison, Daniel M.
Syc, Stephanie B.
Calabresi, Peter A.
Reich, Daniel S.
المصدر
Multiple Sclerosis International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To characterize MR signal changes associated with tissue damage in the fornix and cingulum in multiple sclerosis (MS) using quantitative MRI measures and to determine associations with cognitive dysfunction.
Background.
The fornix and cingulum are white-matter bundles that carry information related to cognition.
While cognitive dysfunction is reported in 40–60% of MS patients, the neuroanatomical correlates of cognitive impairment remain incompletely understood.
Methods.
The cingulum, pillars of the fornix, and corticospinal tract were segmented by fiber tracking via diffusion tensor imaging.
Average tract-specific fractional anisotropy (FA), mean diffusivity (MD), and magnetization transfer ratio (MTR) were compared in MS cases and healthy volunteers.
Associations with clinical measures and neuropsychological tests were derived by multivariate linear regression.
Results.
Fornix FA (P=0.004) and MTR (P=0.005) were decreased, and fornix MD (P<0.001) and cingulum MD (P<0.001) increased, in MS cases (n=101) relative to healthy volunteers (n=16) after adjustment for age and sex.
Lower fornix FA and MTR, and higher fornix MD and λ∥, were correlated with lower PASAT-3 scores, but not with slower 25FTW times.
Lower PASAT-3 scores were associated with lower cingulum FA and higher MD and λ⊥.
Conclusions.
Cognitive dysfunction in MS may involve damage to a widespread network of brain structures, including white-matter pathways within the limbic system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Syc, Stephanie B.& Harrison, Daniel M.& Saidha, Shiv& Seigo, Michaela& Calabresi, Peter A.& Reich, Daniel S.. 2013. Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502230
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Syc, Stephanie B.…[et al.]. Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis. Multiple Sclerosis International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-502230
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Syc, Stephanie B.& Harrison, Daniel M.& Saidha, Shiv& Seigo, Michaela& Calabresi, Peter A.& Reich, Daniel S.. Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502230
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502230
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر