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Matrix Metalloproteinases-9 (MMPs-9) and -12 Are Upregulated in the Airways of Mice with Chronic Airway Inflammation and Remodeling
المؤلفون المشاركون
Chiba, Yoshihiko
Sakai, Hiroyasu
Misawa, Miwa
Yu, Yingyan
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
In the present study, we tried to develop a mouse model of chronic airway inflammation and remodeling induced by chronic exposure to antigen.
Furthermore, the expressions of MMPs-9 and -12 were also investigated.
BALB/c mice were sensitized and then repeatedly challenged with OVA every 3 days for 54 days.
At the following day after the last challenge, of days 24, 39, and 54, histological changes of the airways were studied by hematoxylin-eosin and Masson's trichrome stains.
The expressions of MMPs-9 and -12 were also measured by western blot.
Persistent inflammatory cells infiltration and collagen deposition in the lung tissue were observed in repeatedly challenged mice.
Furthermore, the expressions of MMPs-9 and -12 were increased in the airways after repeated antigen challenges.
The severest inflammation was observed in the day-54 challenged group.
These results suggest that MMPs-9 and -12 might be involved in the pathogenesis of chronic airway inflammation and remodeling induced by antigen exposure in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Yingyan& Sakai, Hiroyasu& Misawa, Miwa& Chiba, Yoshihiko. 2012. Matrix Metalloproteinases-9 (MMPs-9) and -12 Are Upregulated in the Airways of Mice with Chronic Airway Inflammation and Remodeling. ISRN Pulmonology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-502401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Yingyan…[et al.]. Matrix Metalloproteinases-9 (MMPs-9) and -12 Are Upregulated in the Airways of Mice with Chronic Airway Inflammation and Remodeling. ISRN Pulmonology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-502401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Yingyan& Sakai, Hiroyasu& Misawa, Miwa& Chiba, Yoshihiko. Matrix Metalloproteinases-9 (MMPs-9) and -12 Are Upregulated in the Airways of Mice with Chronic Airway Inflammation and Remodeling. ISRN Pulmonology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-502401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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