Structure of N-(3,4-Dimethoxyphenyl)‎pyrido[3′,2′ : 4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases

الملخص EN

The complete crystal structure of N-(3,4-dimethoxyphenyl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine, synthesized via a Dimroth rearrangement and designed as new inhibitor of CLK1 and DYRK1A kinases, was established by a single-crystal X-ray diffraction.

The crystal is orthorhombic, space group Pca21; a = 13.1593 (9), b = 13.9823 (10), c=8.5403 (7) Å, α=β=γ=90°, V = 1571.4 (2)  Å3, and Z=4, C17H14N4O2S.

Solid-state data could be used to enlighten the biological mechanism of action.