Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma
المؤلفون المشاركون
Yano, Yoshihiko
Tanaka, Motofumi
Saito, Masaya
Rinonce, Hanggoro Tri
Hirano, Hirotaka
Takebe, Atsushi
Anggorowati, Nungki
Kuramitsu, Kaori
Bai, Fugui
Widasari, Dewiyani Indah
Hayakumo, Takanobu
Seo, Yasushi
Azuma, Takeshi
Ku, Yonson
Hayashi, Yoshitake
Fukumoto, Takumi
المصدر
International Journal of Hepatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Pregenomic RNA (pgRNA) is generated from covalently closed circular DNA (cccDNA) and plays important roles in viral genome amplification and replication.
Hepatic pgRNA and cccDNA expression levels indicate viral persistence and replication activity.
This study was aimed to measure hepatic pgRNA and cccDNA expression levels in various states of hepatitis B virus (HBV) infection.
Thirty-eight hepatocellular carcinoma (HCC) patients, including 14 positive for hepatitis B surface antigen (HBsAg) and 24 negative for HBsAg but positive for anti-hepatitis B core (anti-HBc) antibody, were enrolled in this study.
In HBsAg-negative but anti-HBc-positive group, HBV-DNA was detected in 20 of 24 (83%) noncancerous liver tissues for at least two genomic regions based on polymerase chain reaction (PCR) analysis.
pgRNA and cccDNA expression levels in occult HBV-infected patients were significantly lower than those in HBsAg-positive patients (P<0.001).
pgRNA and cccDNA in cancerous tissues were also detected without significant difference from those in noncancerous tissues.
In conclusion, cccDNA and pgRNA are detected and represented HBV replication not only in noncancerous but also in cancerous liver tissues.
In addition, the replication is shown in not only patients with HBsAg-positive but also occult HBV-infected patients, suggesting the contribution to HCC development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bai, Fugui& Yano, Yoshihiko& Fukumoto, Takumi& Takebe, Atsushi& Tanaka, Motofumi& Kuramitsu, Kaori…[et al.]. 2013. Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bai, Fugui…[et al.]. Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma. International Journal of Hepatology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-503105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bai, Fugui& Yano, Yoshihiko& Fukumoto, Takumi& Takebe, Atsushi& Tanaka, Motofumi& Kuramitsu, Kaori…[et al.]. Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر