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A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo
المؤلفون المشاركون
Gong, Zipeng
Ai, Ting
He, Haibo
Chen, Tao
Yu, Xueqin
Hu, Wei
Wang, Jing
Zhan, Ling
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Cinobufagin has been widely used in the treatment of carcinoma and plays an important role in the relief of cancer pain.
But the involved mechanism remains unknown.
Aim.
To investigate the changes in thermal and mechanical hyperalgesia in paw cancer pain in mice and the action mechanism of cinobufagin using a paw cancer pain model.
Methods.
60 female mice were randomly divided into 5 groups: control group, model group, cinobufagin group, cinobufagin +NAL-M group, and morphine group; except ones in control group, mice were inoculated with H22 hepatoma cells in the right hind paw.
From the 9th day after inoculation, mice were administrated drug once daily lasting for 8 days.
The pain behavior was determined on the 2nd, 4th, 6th, and 8th days before and after administration.
On the last day, they were sacrificed.
The levels of β-END, CRF, and IL-1β were analyzed by ELISA; immunohistochemistry was performed to detect the expressions of β-END, POMC, and μ-OR in the tumor and adjacent tissue.
Results.
The thresholds of thermal pain and mechanical pain were significantly increased by cinobufagin.
Moreover, the expressions of β-END, CRF, POMC, and μ-OR were significantly upregulated by cinobufagin.
The analgesic effect of cinobufagin was blocked by the peripheral opioid receptor antagonist NAL-M.
Conclusions.
Cinobufagin significantly relieved cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β-END and μ-OR in the hind paw tumor and adjacent tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Tao& Hu, Wei& He, Haibo& Gong, Zipeng& Wang, Jing& Yu, Xueqin…[et al.]. 2013. A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Tao…[et al.]. A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-503284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Tao& Hu, Wei& He, Haibo& Gong, Zipeng& Wang, Jing& Yu, Xueqin…[et al.]. A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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