Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK
المؤلفون المشاركون
Cui, Mingxia
Yu, Han
Li, Ji
Gao, Junjie
Wang, Jinli
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
To investigate the role of AMPK activation and autophagy in mediating the beneficial effects of exercise and caloric restriction in obesity.
Methods.
Dietary-induced obesity mice were made and divided into 5 groups; one additional group of normal mice serves as control.
Mice in each group received different combinations of interventions including low fat diet, caloric restriction, and exercise.
Then their metabolic conditions were assessed by measuring serum glucose and insulin, serum lipids, and liver function.
AMPK phosphorylation and autophagy activity were detected by western blotting.
Results.
Obese mice models were successfully induced by high fat diet.
Caloric restriction consistently improved the metabolic conditions of the obese mice, and the effects are more prominent than the mice that received only exercise.
Also, caloric restriction, exercise, and low fat diet showed a synergistic effect in the improvement of metabolic conditions.
Western blotting results showed that this improvement was not related with the activation of AMPK in liver, skeletal muscle, or heart but correlates well with the autophagy activity.
Conclusion.
Caloric restriction has more prominent beneficial effects than exercise in dietary-induced obese mice.
These effects are correlated with the autophagy activity and may be independent of AMPK activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Mingxia& Yu, Han& Wang, Jinli& Gao, Junjie& Li, Ji. 2013. Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503441
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Mingxia…[et al.]. Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-503441
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Mingxia& Yu, Han& Wang, Jinli& Gao, Junjie& Li, Ji. Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-503441
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503441
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر