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Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors
المؤلفون المشاركون
Lindström, Mikael S.
Nistér, Monica
Hede, Sanna-Maria
Nazarenko, Inga
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Malignant glioma is the most common brain tumor in adults and is associated with a very poor prognosis.
Mutations in the p53 tumor suppressor gene are frequently detected in gliomas.
p53 is well-known for its ability to induce cell cycle arrest, apoptosis, senescence, or differentiation following cellular stress.
That the guardian of the genome also controls stem cell self-renewal and suppresses pluripotency adds a novel level of complexity to p53.
Exactly how p53 works in order to prevent malignant transformation of cells in the central nervous system remains unclear, and despite being one of the most studied proteins, there is a need to acquire further knowledge about p53 in neural stem cells.
Importantly, the characterization of glioma cells with stem-like properties, also known as brain tumor stem cells, has opened up for the development of novel targeted therapies.
Here, we give an overview of what is currently known about p53 in brain tumors and neural stem cells.
Specifically, we review the literature regarding transformation of adult neural stem cells and, we discuss how the loss of p53 and deregulation of growth factor signaling pathways, such as increased PDGF signaling, lead to brain tumor development.
Reactivation of p53 in brain tumor stem cell populations in combination with current treatments for glioma should be further explored and may become a viable future therapeutic approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hede, Sanna-Maria& Nazarenko, Inga& Nistér, Monica& Lindström, Mikael S.. 2010. Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors. Journal of Oncology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-503466
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hede, Sanna-Maria…[et al.]. Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors. Journal of Oncology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-503466
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hede, Sanna-Maria& Nazarenko, Inga& Nistér, Monica& Lindström, Mikael S.. Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors. Journal of Oncology. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-503466
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503466
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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