Lack of Restoration in Vivo by K+-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge
المؤلفون المشاركون
Whitelaw, C. C.
Morrison, J. D.
Gilligan, L. C.
Lucas, M. L.
Wynne, P. J.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Enhanced potassium ion permeability at the enterocyte basolateral membrane is assumed to facilitate sustained chloride ion and fluid secretion into the intestinal lumen during episodes of secretory diarrhoeal disease.
To examine this concept in vivo, two potassium ion channel blockers and a channel opener were coperfused with E.
coli heat stable STa enterotoxin to determine whether such compounds improved or worsened the inhibited fluid absorption.
In the STa (80 ng/mL) challenged jejunal loop, the fluid absorption rate of 28.6 ± 5.8 (14) μL/cm/hr was significantly below (P<.001) the normal rate of 98.8 ± 6.2 (17) μL/cm/hr.
Intraluminal (300 uM) glibenclamide added to STa perfused loops failed to improve the inhibited fluid absorption rate, which was 7.4 ± 3.2 (6) μL/cm/hr on coperfusion with STa.
Similarly, on coperfusion with 30 uM clotrimazole, the fluid absorption rate with STa present remained inhibited at 11.4 ± 7.0 (4) μL/cm/hr.
On coperfusion with intraluminal 1 uM cromakalim, STa reduced fluid absorption significantly (P<.02) to 24.7 ± 8.0 (10) μL/cm/hr, no different from STa challenge in the absence of cromakalim.
Infusion i.v.
with these agents also failed to restore fluid absorption after STa challenge.
These observations do not support the proposed potassium ion permeability event as a necessary corollary of enterotoxin-mediated secretion.
This makes it unlikely that modulators of such permeability prevent enterocyte secretion in diarrhoeal disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lucas, M. L.& Gilligan, L. C.& Whitelaw, C. C.& Wynne, P. J.& Morrison, J. D.. 2011. Lack of Restoration in Vivo by K+-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge. Journal of Tropical Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-503530
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lucas, M. L.…[et al.]. Lack of Restoration in Vivo by K+-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge. Journal of Tropical Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-503530
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lucas, M. L.& Gilligan, L. C.& Whitelaw, C. C.& Wynne, P. J.& Morrison, J. D.. Lack of Restoration in Vivo by K+-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge. Journal of Tropical Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-503530
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503530
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر