IMMUNOCAT—A Data Management System for Epitope Mapping Studies
المؤلفون المشاركون
Chung, Jo L.
Sette, Alessandro
Sun, Jian
Sidney, John
Peters, Bjoern
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
To enable rationale vaccine design, studies of molecular and cellular mechanisms of immune recognition need to be linked with clinical studies in humans.
A major challenge in conducting such translational research studies lies in the management and integration of large amounts and various types of data collected from multiple sources.
For this purpose, we have established “IMMUNOCAT”, an interactive data management system for the epitope discovery research projects conducted by our group.
The system provides functions to store, query, and analyze clinical and experimental data, enabling efficient, systematic, and integrative data management.
We demonstrate how IMMUNOCAT is utilized in a large-scale research contract that aims to identify epitopes in common allergens recognized by T cells from human donors, in order to facilitate the rational design of allergy vaccines.
At clinical sites, demographic information and disease history of each enrolled donor are captured, followed by results of an allergen skin test and blood draw.
At the laboratory site, T cells derived from blood samples are tested for reactivity against a panel of peptides derived from common human allergens.
IMMUNOCAT stores results from these T cell assays along with MHC:peptide binding data, results from RAST tests for antibody titers in donor serum, and the respective donor HLA typing results.
Through this system, we are able to perform queries and integrated analyses of the various types of data.
This provides a case study for the use of bioinformatics and information management techniques to track and analyze data produced in a translational research study aimed at epitope identification.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chung, Jo L.& Sun, Jian& Sidney, John& Sette, Alessandro& Peters, Bjoern. 2010. IMMUNOCAT—A Data Management System for Epitope Mapping Studies. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-503759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chung, Jo L.…[et al.]. IMMUNOCAT—A Data Management System for Epitope Mapping Studies. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-503759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chung, Jo L.& Sun, Jian& Sidney, John& Sette, Alessandro& Peters, Bjoern. IMMUNOCAT—A Data Management System for Epitope Mapping Studies. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-503759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر