Evaluation of the Biocompatibility of a Bilayer Chitosan Skin Regenerating Template, Human Skin Allograft, and Integra Implants in Rats
المؤلفون المشاركون
Jaafar, Hasnan
Mat Saad, Arman Zaharil
Halim, Ahmad Sukari
Mohd Yussof, Shah Jumaat
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Chitosan is a nontoxic, biocompatible, and biodegradable polymer obtained from chitin by N-deacetylation using strong alkali.
Chitosan in a form of a bilayer skin regenerating template can act as a scaffold for regeneration.
Integra is a two-layer skin regeneration system, constructed of a matrix of crosslinked fibers that acts as a scaffold for regenerating dermal skin cells.
Human skin allografts (HSAs) are the “gold standard” for temporary coverage of clean burn wounds.
Objectives.
The objective of this study was to conduct in-vivo, preclinical biocompatibility evaluations of Integra, HSA, and Chitosan skin regenerating template (SRT).
Methods.
Paravertebral subcutaneous pockets were created for the implantation of test materials.
Implants were retrieved after 4, 7, 14, 21, and 28 days.
Slides of sections through the implants were examined to determine biocompatibility.
Results.
Chitosan SRT and Integra showed similar inflammatory patterns.
HSA showed a higher inflammatory reaction initially which then reduced to levels similar to Integra and Chitosan SRT.
Chitosan SRT and Integra also shared similar angiogenesis levels.
Towards the end, all implants were degraded with decreased tissue response.
Conclusion.
Integra, Chitosan SRT, and HSA have been shown to be biocompatible.
Integra and Chitosan SRT seem to illicit similar tissue responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohd Yussof, Shah Jumaat& Halim, Ahmad Sukari& Mat Saad, Arman Zaharil& Jaafar, Hasnan. 2011. Evaluation of the Biocompatibility of a Bilayer Chitosan Skin Regenerating Template, Human Skin Allograft, and Integra Implants in Rats. ISRN Materials Science،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-503824
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohd Yussof, Shah Jumaat…[et al.]. Evaluation of the Biocompatibility of a Bilayer Chitosan Skin Regenerating Template, Human Skin Allograft, and Integra Implants in Rats. ISRN Materials Science No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-503824
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohd Yussof, Shah Jumaat& Halim, Ahmad Sukari& Mat Saad, Arman Zaharil& Jaafar, Hasnan. Evaluation of the Biocompatibility of a Bilayer Chitosan Skin Regenerating Template, Human Skin Allograft, and Integra Implants in Rats. ISRN Materials Science. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-503824
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503824
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر