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Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy : The Underlying Mechanisms and Clinical Management
المؤلف
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-17
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأمراض
الملخص EN
Immunomodulation with the anti-CTLA-4 monoclonal antibody ipilimumab has been shown to extend overall survival (OS) in previously treated and treatment-naive patients with unresectable stage III or IV melanoma.
Blockade of CTLA-4 signaling with ipilimumab prolongs T-cell activation and restores T-cell proliferation, thus amplifying T-cell-mediated immunity and the patient's capacity to mount an effective antitumor immune response.
While this immunostimulation has unprecedented OS benefits in the melanoma setting, it can also result in immune-mediated effects on various organ systems, leading to immune-related adverse events (irAEs).
Ipilimumab-associated irAEs are common and typically low grade and manageable, but can also be serious and life threatening.
The skin and gastrointestinal tract are most frequently affected, while hepatic, endocrine, and neurologic events are less common.
With proper management, most irAEs resolve within a relatively short time, with a predictable resolution pattern.
Prompt and appropriate management of these irAEs is essential and treatment guidelines have been developed to assist oncologists and their teams.
Implementation of these irAE management algorithms will help ensure that patients are able to benefit from ipilimumab therapy with adequate control of toxicities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tarhini, Ahmad. 2013. Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy : The Underlying Mechanisms and Clinical Management. Scientifica،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-503833
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tarhini, Ahmad. Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy : The Underlying Mechanisms and Clinical Management. Scientifica No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-503833
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tarhini, Ahmad. Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy : The Underlying Mechanisms and Clinical Management. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-503833
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503833
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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