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Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease
المؤلفون المشاركون
Brasnjevic, I.
Kholod, N.
Martinez-Martinez, P.
van Os, J.
van Leeuwen, F. W.
Rutten, B. P. F.
Prickaerts, J.
van den Hove, D. L. A.
Lemmens, M. A. M.
Steinbusch, H. W. M.
Chouliaras, L.
Kenis, G.
Hof, P. R.
Losen, M.
van Donkelaar, E. L.
Sierksma, A. S. R.
De Baets, M. H.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-27، 27ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-05
دولة النشر
مصر
عدد الصفحات
27
التخصصات الرئيسية
الملخص EN
The etiology of the sporadic form of Alzheimer's disease (AD) remains largely unknown.
Recent evidence has suggested that gene-environment interactions (GxE) may play a crucial role in its development and progression.
Whereas various susceptibility loci have been identified, like the apolipoprotein E4 allele, these cannot fully explain the increasing prevalence of AD observed with aging.
In addition to such genetic risk factors, various environmental factors have been proposed to alter the risk of developing AD as well as to affect the rate of cognitive decline in AD patients.
Nevertheless, aside from the independent effects of genetic and environmental risk factors, their synergistic participation in increasing the risk of developing AD has been sparsely investigated, even though evidence points towards such a direction.
Advances in the genetic manipulation of mice, modeling various aspects of the AD pathology, have provided an excellent tool to dissect the effects of genes, environment, and their interactions.
In this paper we present several environmental factors implicated in the etiology of AD that have been tested in transgenic animal models of the disease.
The focus lies on the concept of GxE and its importance in a multifactorial disease like AD.
Additionally, possible mediating mechanisms and future challenges are discussed.Erratum of Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Diseasedx.doi.org/10.4061/2010/356862
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chouliaras, L.& Sierksma, A. S. R.& Kenis, G.& Prickaerts, J.& Lemmens, M. A. M.& Brasnjevic, I.…[et al.]. 2010. Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-27.
https://search.emarefa.net/detail/BIM-503966
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chouliaras, L.…[et al.]. Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-27.
https://search.emarefa.net/detail/BIM-503966
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chouliaras, L.& Sierksma, A. S. R.& Kenis, G.& Prickaerts, J.& Lemmens, M. A. M.& Brasnjevic, I.…[et al.]. Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-27.
https://search.emarefa.net/detail/BIM-503966
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503966
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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