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Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas
المؤلفون المشاركون
Hayes, M. Geoffrey
Klein, Barbara E. K.
Klein, Ronald
Gonzalez, Victor H.
Hanis, Craig L.
Hallman, D. Michael
Fu, Yi-Ping
Bell, Graeme I.
Cox, Nancy J.
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To identify genetic loci for severe diabetic retinopathy, 286 Mexican-Americans with type 2 diabetes from Starr County, Texas, completed physical examinations including fundus photography for diabetic retinopathy grading.
Individuals with moderate-to-severe non-proliferative and proliferative diabetic retinopathy were defined as cases.
Direct genotyping was performed using the Affymetrix GeneChip Human Mapping 100 K Set, and SNPs passing quality control criteria were used to impute markers available in HapMap Phase III Mexican population (MXL) in Los Angeles, California.
Two directly genotyped markers were associated with severe diabetic retinopathy at a P-value less than .0001: SNP rs2300782 (P=6.04×10−5) mapped to an intron region of CAMK4 (calcium/calmodulin-dependent protein kinase IV) on chromosome 5, and SNP rs10519765 (P=6.21×10−5) on chromosomal 15q13 in the FMN1 (formin 1) gene.
Using well-imputed markers based on the HapMap III Mexican population, we identified an additional 32 SNPs located in 11 chromosomal regions with nominal association with severe diabetic retinopathy at P-value less than .0001.
None of these markers were located in traditional candidate genes for diabetic retinopathy or diabetes itself.
However, these signals implicate genes involved in inflammation, oxidative stress and cell adhesion for the development and progression of diabetic retinopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Yi-Ping& Hallman, D. Michael& Gonzalez, Victor H.& Klein, Barbara E. K.& Klein, Ronald& Hayes, M. Geoffrey…[et al.]. 2010. Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas. Journal of Ophthalmology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Yi-Ping…[et al.]. Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas. Journal of Ophthalmology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-504159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Yi-Ping& Hallman, D. Michael& Gonzalez, Victor H.& Klein, Barbara E. K.& Klein, Ronald& Hayes, M. Geoffrey…[et al.]. Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas. Journal of Ophthalmology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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