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Nephroprotective Effect of POLYCAN on Acute Renal Failure Induced by Cisplatin in Rats
المؤلفون المشاركون
Kim, Ki-Young
Moon, Seung-Bae
Lee, Young-Joon
Ku, Sae-Kwang
Lee, Sung-Dong
Kim, Joo Wan
Kwon, Young-Sam
Cho, Hyung-Rae
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
We performed to evaluate the effect of POLYCAN (β-glucan) on cisplatin-(CDDP-)induced acute renal failure (ARF) in rats.
POLYCAN was administered orally once a day for 32 days.
Each of 8 rats per group was selected based on the body weight (BW) after acclimatization and they were sacrificed at 5 days after CDDP injection.
There was significant (P<0.05) increase of BW after CDDP dosing in all POLYCAN groups than vehicle control and significant (P<0.01 or P<0.05) decrease of absolute and relative kidney weight were detected in all POLYCAN groups compared with vehicle control.
In addition, serum BUN and creatinine level in all POLYCAN groups were significantly (P<0.01 or P<0.05) lower than vehicle control and the percentage of degenerative regions significantly (P<0.01) decreased in all POLYCAN groups.
As the results of CDDP-induced ARF process, dramatic decrease of the BW, increase of the kidney weight, serum BUN, and creatinine level were detected in vehicle control group compared with sham control group.
The changes by CDDP-induced ARF process in POLYCAN groups were significantly and dose-dependently improved compared with vehicle control group.
Therefore, POLYCAN has enough potential to develop as a new agent of prevention or treatment for ARF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ku, Sae-Kwang& Lee, Young-Joon& Lee, Sung-Dong& Cho, Hyung-Rae& Moon, Seung-Bae& Kim, Ki-Young…[et al.]. 2012. Nephroprotective Effect of POLYCAN on Acute Renal Failure Induced by Cisplatin in Rats. ISRN Veterinary Science،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504252
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ku, Sae-Kwang…[et al.]. Nephroprotective Effect of POLYCAN on Acute Renal Failure Induced by Cisplatin in Rats. ISRN Veterinary Science No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-504252
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ku, Sae-Kwang& Lee, Young-Joon& Lee, Sung-Dong& Cho, Hyung-Rae& Moon, Seung-Bae& Kim, Ki-Young…[et al.]. Nephroprotective Effect of POLYCAN on Acute Renal Failure Induced by Cisplatin in Rats. ISRN Veterinary Science. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504252
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504252
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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