Detection of M-Sequences from Spike Sequence in Neuronal Networks

الملخص EN

In circuit theory, it is well known that a linear feedback shift register (LFSR) circuit generates pseudorandom bit sequences (PRBS), including an M-sequence with the maximum period of length.

In this study, we tried to detect M-sequences known as a pseudorandom sequence generated by the LFSR circuit from time series patterns of stimulated action potentials.

Stimulated action potentials were recorded from dissociated cultures of hippocampal neurons grown on a multielectrode array.

We could find several M-sequences from a 3-stage LFSR circuit (M3).

These results show the possibility of assembling LFSR circuits or its equivalent ones in a neuronal network.

However, since the M3 pattern was composed of only four spike intervals, the possibility of an accidental detection was not zero.

Then, we detected M-sequences from random spike sequences which were not generated from an LFSR circuit and compare the result with the number of M-sequences from the originally observed raster data.

As a result, a significant difference was confirmed: a greater number of “0–1” reversed the 3-stage M-sequences occurred than would have accidentally be detected.

This result suggests that some LFSR equivalent circuits are assembled in neuronal networks.