Association of Interferon-Alpha and Ribavirin-Induced Thyroid Dysfunction with Severity of Disease and Response to Treatment in Pakistani Asian Patients of Chronic Hepatitis C

المؤلفون المشاركون

Aslam, Muhammad
Nadeem, Amina

المصدر

Hepatitis Research and Treatment

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-09-02

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأمراض

الملخص EN

Objective.

To determine the association of thyroid dysfunction with the severity of the disease and response to treatment in patients of chronic hepatitis C.

Design.

Cohort study.

Patients.

One hundred and sixty seven noncirrhotic chronic hepatitis C patients were grouped into treatment group (n=107) and control group (n=60).

Measurements.

Baseline S.

ALT and S.

AST by IFCC and S.

TSH, S.

free T4, and S.T3 level were measured by chemiluminescence method.

The severity of the disease was measured by Knodell histopathological index (HPI) on liver biopsy.

Study group patients underwent 24-weeks IFN and ribavirin therapy and thyroid functions were determined at weeks 0, 12, and 24.

Response to therapy was determined by PCR-HCV test.

Results.

20 treated patients (18.69%) developed thyroid dysfunction with relative risk (RR) of 11.25 and attributable risk (AR) of 91%.

Females were at higher risk.

Hypothyroidism was common than hyperthyroidism.

There was no significant association between thyroid dysfunction and severity of the disease (P=0.81) and response to therapy (P=0.79).

Conclusion.

Interferon-alpha and ribavirin therapy induces thyroid dysfunction in chronic hepatitis C patients.

There is no association between severity of disease and response to therapy with interferon-induced thyroid dysfunction.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nadeem, Amina& Aslam, Muhammad. 2012. Association of Interferon-Alpha and Ribavirin-Induced Thyroid Dysfunction with Severity of Disease and Response to Treatment in Pakistani Asian Patients of Chronic Hepatitis C. Hepatitis Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504475

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nadeem, Amina& Aslam, Muhammad. Association of Interferon-Alpha and Ribavirin-Induced Thyroid Dysfunction with Severity of Disease and Response to Treatment in Pakistani Asian Patients of Chronic Hepatitis C. Hepatitis Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-504475

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nadeem, Amina& Aslam, Muhammad. Association of Interferon-Alpha and Ribavirin-Induced Thyroid Dysfunction with Severity of Disease and Response to Treatment in Pakistani Asian Patients of Chronic Hepatitis C. Hepatitis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-504475

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-504475