Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys
المؤلفون المشاركون
Negus, S. Stevens
Morrissey, Ember M.
Folk, John E.
Rice, Kenner C.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Delta opioid agonists enhance antinociceptive effects of mu-opioid agonists in many preclinical assays of acute nociception, but delta/mu interactions in preclinical models of inflammation-associated pain have not been examined.
This study examined interactions between the delta agonist SNC80 [(+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and the mu agonist analgesics methadone, morphine, and nalbuphine in an assay of capsaicin-induced thermal allodynia in rhesus monkeys.
Thermal allodynia was produced by topical application of capsaicin to the tail.
Antiallodynic effects of methadone, morphine, and nalbuphine were evaluated alone or in combination with fixed proportions of SNC80 identical to proportions previously shown to enhance acute thermal antinociceptive effects of these mu agonists in rhesus monkeys (0.9 : 1 SNC80/methadone; 0.29 : 1 SNC80/morphine; 3.6 : 1 SNC80/nalbuphine).
Methadone, morphine, and nalbuphine each produced dose-dependent antiallodynia.
SNC80 produced partial antiallodynia up to the highest dose tested (5.6 mg/kg).
SNC80 produced a modest, enantioselective, and naltrindole-reversible enhancement of methadone-induced antiallodynia.
However, SNC80 did not enhance morphine antiallodynia and only weakly enhanced nalbuphine antiallodynia.
Overall, SNC80 produced modest or no enhancement of the antiallodynic effects of the three mu agonists evaluated.
These results suggest that delta agonist-induced enhancement of mu agonist antiallodynia may be weaker and less reliable than previously demonstrated enhancement of mu agonist acute thermal nociception.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Negus, S. Stevens& Morrissey, Ember M.& Folk, John E.& Rice, Kenner C.. 2012. Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-504626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Negus, S. Stevens…[et al.]. Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys. Pain Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-504626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Negus, S. Stevens& Morrissey, Ember M.& Folk, John E.& Rice, Kenner C.. Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-504626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر