Lymphangiogenesis and Axillary Lymph Node Metastases Correlated with VEGF-C Expression in Two Immunocompetent Mouse Mammary Carcinoma Models
المؤلفون المشاركون
Morimoto, Junji
Otsuki, Yoshinori
Ito, Yuko
Shibata, Masa-Aki
Eid, Nabil
المصدر
International Journal of Breast Cancer
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Lymphangiogenesis and the expression of vascular endothelial cell growth factor C (VEGF-C) in tumors have been considered to be causally promoting lymphatic metastasis.
There are only a few studies on lymphatic metastasis in immunocompetent allograft mouse models.
To study the relationship between VEGF-C-mediated lymphangiogenesis and axillary lymph node metastasis, we used two mouse mammary carcinoma cell lines; the BJMC338 has a low metastatic propensity, whereas the BJMC3879 has a high metastatic propensity although it originated from the former cell line.
Each cell line was injected separately into two groups of female BALB/c mice creating in vivo mammary cancer models.
The expression level of VEGF-C in BJMC3879 was higher than BJMC338.
As the parent cell line, BJMC3879-derived tumors showed higher expression of VEGF-C compared to BJMC338-derived tumors.
This higher expression of VEGF-C in BJMC3879-derived tumors was associated with marked increase in infiltrating macrophages and enhanced expression of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) reflecting increased tumoral lymphatic density and subsequent induction of axillary lymph node metastasis.
Our mouse mammary carcinoma models are allotransplanted tumors showing the same axillary lymph node metastatic spectrum as human breast cancers.
Therefore, our mouse models are ideal for exploring the various molecular mechanisms of cancer metastasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ito, Yuko& Shibata, Masa-Aki& Eid, Nabil& Morimoto, Junji& Otsuki, Yoshinori. 2011. Lymphangiogenesis and Axillary Lymph Node Metastases Correlated with VEGF-C Expression in Two Immunocompetent Mouse Mammary Carcinoma Models. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-504637
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ito, Yuko…[et al.]. Lymphangiogenesis and Axillary Lymph Node Metastases Correlated with VEGF-C Expression in Two Immunocompetent Mouse Mammary Carcinoma Models. International Journal of Breast Cancer No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-504637
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ito, Yuko& Shibata, Masa-Aki& Eid, Nabil& Morimoto, Junji& Otsuki, Yoshinori. Lymphangiogenesis and Axillary Lymph Node Metastases Correlated with VEGF-C Expression in Two Immunocompetent Mouse Mammary Carcinoma Models. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-504637
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504637
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر