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Determinants of Mortality among Adult HIV-Infected Patients on Antiretroviral Therapy in a Rural Hospital in Southeastern Nigeria : A 5-Year Cohort Study
المؤلفون المشاركون
Eseigbe, Cynthia E.
Eguzo, Kelechi N.
Umezurike, Chisara C.
Lawal, Adegboyega K.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Study examined the determinants of mortality among adult HIV patients in a rural, tertiary hospital in southeastern Nigeria, comparing mortality among various ART regimens.
Methods.
Retrospective cohort study of 1069 patients on ART between August 2008 and October 2013.
Baseline CD4 counts, age, gender, and ART regimen were considered in this study.
Kaplan-Meier method was used to estimate survival and Cox proportional hazards models to identify multivariate predictors of mortality.
Median follow-up period was 24 months (IQR 6–45).
Results.
78 (7.3%) patients died with 15.6% lost to followup.
Significant independent predictors of mortality include age (>45), sex (male > female), baseline CD4 stage (<200), and ART combination.
Adjusted mortality hazard was 3 times higher among patients with CD4 count <200 cells/μL than those with counts >500 (95% CI 1.69–13.59).
Patients on Truvada-based first-line regimens were 88% more likely to die than those on Combivir-based first line (95% CI 1.05–3.36), especially those with CD4 count <200 cells/μL.
Conclusion.
Study showed lower mortality than most studies in Nigeria and Africa, with mortality higher among males and patients with CD4 count <200.
Further studies are recommended to further compare treatment outcomes between Combivir- and Truvada-based regimens in resource-limited settings using clinical indicators.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eguzo, Kelechi N.& Lawal, Adegboyega K.& Eseigbe, Cynthia E.& Umezurike, Chisara C.. 2014. Determinants of Mortality among Adult HIV-Infected Patients on Antiretroviral Therapy in a Rural Hospital in Southeastern Nigeria : A 5-Year Cohort Study. AIDS Research and Treatment،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-504699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eguzo, Kelechi N.…[et al.]. Determinants of Mortality among Adult HIV-Infected Patients on Antiretroviral Therapy in a Rural Hospital in Southeastern Nigeria : A 5-Year Cohort Study. AIDS Research and Treatment No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-504699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eguzo, Kelechi N.& Lawal, Adegboyega K.& Eseigbe, Cynthia E.& Umezurike, Chisara C.. Determinants of Mortality among Adult HIV-Infected Patients on Antiretroviral Therapy in a Rural Hospital in Southeastern Nigeria : A 5-Year Cohort Study. AIDS Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-504699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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