Potential Smoothened Inhibitor from Traditional Chinese Medicine against the Disease of Diabetes, Obesity, and Cancer
المؤلفون المشاركون
Chen, Calvin Yu-Chian
Lee, Cheng-Chun
Chen, Calvin Yu-Chian
Chen, Kuan-Chung
Sun, Mao-Feng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Nowadays, obesity becomes a serious global problem, which can induce a series of diseases such as type 2 diabetes mellitus, cancer, cardiovascular disease, metabolic syndrome, and stoke.
For the mechanisms of diseases, the hedgehog signaling pathway plays an important role in body patterning during embryogenesis.
For this reason, smoothened homologue (Smo) protein had been indicated as the drug target.
In addition, the small-molecule Smo inhibitor had also been used in oncology clinical trials.
To improve drug development of TCM compounds, we aim to investigate the potent lead compounds as Smo inhibitor from the TCM compounds in TCM Database@Taiwan.
The top three TCM compounds, precatorine, labiatic acid, and 2,2′-[benzene-1,4-diylbis(methanediyloxybenzene-4,1-diyl)]bis(oxoacetic acid), have displayed higher potent binding affinities than the positive control, LY2940680, in the docking simulation.
After MD simulations, which can optimize the result of docking simulation and validate the stability of H-bonds between each ligand and Smo protein under dynamic conditions, top three TCM compounds maintain most of interactions with Smo protein, which keep the ligand binding stable in the binding domain.
Hence, we propose precatorine, labiatic acid, and 2,2′-[benzene-1,4-diylbis(methanediyloxybenzene-4,1-diyl)]bis(oxoacetic acid) as potential lead compounds for further study in drug development process with the Smo protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Kuan-Chung& Sun, Mao-Feng& Chen, Calvin Yu-Chian& Lee, Cheng-Chun& Chen, Calvin Yu-Chian. 2014. Potential Smoothened Inhibitor from Traditional Chinese Medicine against the Disease of Diabetes, Obesity, and Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-505166
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Kuan-Chung…[et al.]. Potential Smoothened Inhibitor from Traditional Chinese Medicine against the Disease of Diabetes, Obesity, and Cancer. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-505166
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Kuan-Chung& Sun, Mao-Feng& Chen, Calvin Yu-Chian& Lee, Cheng-Chun& Chen, Calvin Yu-Chian. Potential Smoothened Inhibitor from Traditional Chinese Medicine against the Disease of Diabetes, Obesity, and Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-505166
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505166
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر