Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes
المؤلفون المشاركون
Haffty, Bruce G.
Moran, Meena S.
Lannin, Donald R.
Castrucci, William
Higgins, Susan A.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
The value of nodal ratios (NRs) as a prognostic variable in breast cancer is continually being demonstrated.
The purpose of this study was to use NR in patients with ≥4+ nodes to assess a correlation of NR with regional (lymph node) recurrence.
Methods.
Inclusion criteria was ≥8 nodes dissected with ≥4+ nodes after breast conservation therapy.
Of 1060 patients treated from 1975 to 2003 who had a minimum of 8 nodes dissected, 273 were node+; 56 patients had ≥4+ involved nodes and were the focus of this study.
Nodal ratios were calculated for each patient and grouped into 3 categories: high (≥70%), intermediate (40%–69%) and low (<40%).
Each nodal ratio was correlated with patterns of local, regional, and distant failures and OS.
Results.
Outcomes for the entire cohort were BRFS-83%, NRFS-93%, DMFS-61%, and OS 63% at 10 yrs.
The OS, DMFS, and NRFS correlated with N2 (4–9 nodes+) versus N3 (≥10+) status but did not correlate with BRFS, as expected.
When evaluating NR, 18 pts had high NR (>70%).
Only 3 patients experienced nodal recurrences, all within previously radiated supraclavicular fields.
All 3 in-field regional failures occurred in the N3 group of patients with NR >70%.
All were treated with a single AP field prescribed to a dose of 46 Gy at a standard depth of 3 cm.
Conclusions.
In this group of N2/N3 patients treated with BCT, we were able to identify patients at high risk for regional failures as those with high NR of >70% and ≥10+ nodes.
While these findings need to be reproduced in larger datasets, this group of patients with NR of >70% in 4 or more positive axillary lymph nodes may benefit from meticulous targeting of regional nodes, dose escalation, and/or more intensive systemic therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castrucci, William& Lannin, Donald R.& Haffty, Bruce G.& Higgins, Susan A.& Moran, Meena S.. 2011. Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes. ISRN Surgery،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-505323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castrucci, William…[et al.]. Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes. ISRN Surgery No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-505323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castrucci, William& Lannin, Donald R.& Haffty, Bruce G.& Higgins, Susan A.& Moran, Meena S.. Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes. ISRN Surgery. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-505323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر