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Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population
المؤلفون المشاركون
Tamm, Ann E.
Tamm, Agu O.
Kisand, Kalle
Kumm, Jaanika
Kerna, Irina
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
To investigate associations of selected single-nucleotide polymorphisms (SNPs) in ADAM12 gene with radiographic knee osteoarthritis (rKOA) in Estonian population.
Methods.
The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 438 subjects (303 women) from population-based cohort, aged 32 to 57 (mean 45.4).
The rKOA features were evaluated in the tibiofemoral joint (TFJ) and patellofemoral joint.
Results.
The early rKOA was found in 51.4% of investigated subjects (72% women) and 12.3% of participants (63% women) had advanced stage of diseases.
The A allele of synonymous SNP rs1044122 was associated with early rKOA in TFJ, predominantly with the presence of osteophytes in females (OR 1.57; 95% CI 1.08–2.29, P=0.018).
The C allele of intron polymorphism rs1871054 carried risk for advanced rKOA, mostly to osteophyte formation in TFJ in males (OR 3.03; 95% CI 1.11–7.53, P=0.018).
Also the CCAA haplotype of ADAM12 was associated with osteophytosis, again mostly in TFJ in males (P=0.014).
For rs3740199 and rs1278279, no statistically significant associations were observed.
Conclusion. ADAM12 gene variants are related to rKOA risk during the early and late stages of diseases.
The genetic risk seems to be predominantly associated with the appearance of osteophytes—a marker of bone remodelling and neochondrogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kerna, Irina& Kisand, Kalle& Tamm, Ann E.& Kumm, Jaanika& Tamm, Agu O.. 2013. Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population. Arthritis،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-505546
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kerna, Irina…[et al.]. Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population. Arthritis No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-505546
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kerna, Irina& Kisand, Kalle& Tamm, Ann E.& Kumm, Jaanika& Tamm, Agu O.. Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population. Arthritis. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-505546
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505546
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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