![](/images/graphics-bg.png)
Molecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation
المؤلفون المشاركون
Reyes, Jorge D.
Diamond, Deborah L.
Bryan, Janine T.
Das, Trina
Hassan, Sajida
Perkins, James D.
Yeh, Matthew M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Chronic hepatitis C virus (HCV) induced hepatocellular carcinoma (HCC) is a primary indication for liver transplantation (LT).
In western countries, the estimated rate of HCC recurrence following LT is between 15% and 20% and is a major cause of mortality.
Currently, there is no standard method to treat patients who are at high risk for HCC recurrence.
The aim of this study was to investigate the molecular signatures underlying HCC recurrence that may lead to future studies on gene regulation contributing to new therapeutic options.
Two groups of patients were selected, one including patients with HCV who developed HCC recurrence (HCC-R) ≤3 years from LT and the second group including patients with HCV who did not have recurrent HCC (HCC-NR).
Microarray analysis containing more than 29,000 known genes was performed on formalin-fixed-paraffin-embedded (FFPE) liver tissue from explanted livers.
Gene expression profiling revealed 194 differentially regulated genes between the two groups.
These genes belonged to cellular networks including cell cycle G1/S checkpoint regulators, RAN signaling, chronic myeloid leukemia signaling, molecular mechanisms of cancer, FXR/RXR activation and hepatic cholestasis.
A subset of molecular signatures associated with HCC recurrence was found.
The expression levels of these genes were validated by quantitative PCR analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Das, Trina& Diamond, Deborah L.& Yeh, Matthew M.& Hassan, Sajida& Bryan, Janine T.& Reyes, Jorge D.…[et al.]. 2013. Molecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation. Journal of Transplantation،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-505561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Das, Trina…[et al.]. Molecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation. Journal of Transplantation No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-505561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Das, Trina& Diamond, Deborah L.& Yeh, Matthew M.& Hassan, Sajida& Bryan, Janine T.& Reyes, Jorge D.…[et al.]. Molecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation. Journal of Transplantation. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-505561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)