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Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension : A Preliminary Population-Based Cross-Sectional Study
المؤلفون المشاركون
Guimarães, Andre L. S.
Velasquez-Melendez, Gustavo
Neto, João F. R.
Gomes, Crizian S.
Veloso, Rosângela R.
Reis, Tatiana C.
Pena, Geórgia das Graças
المصدر
Cardiology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors.
The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension.
A cross-sectional study was carried out in individuals aged ≥ 18 years.
Polymorphism identification was performed using PCR-RFLP analysis.
Participants with blood pressure ≥ 140/90 mmHg or medication use were considered hypertensive.
Frequencies, means, cross-tabulations, and multivariate models were produced to study differences in hypertension prevalence by genotypes.
The study includes 470 participants.
The frequency of GG polymorphism variant was 10.43%, 46.81% AG, and 42.77% AA.
The distribution of hypertension frequency by LEPR genotypes was the following: AA 43.8%, AG 40.4%, and GG 40.8%; there were no significant differences between groups.
Comparative analysis which used multivariate Poisson regression adjusted by many potential confounders (age, sex, schooling, smoking, alcohol intake, obesity, and family history of parental obesity) did not modify this result.
In this large sample of population-based study, the association of the LEPR Gln223Arg gene polymorphism with hypertension was not observed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pena, Geórgia das Graças& Guimarães, Andre L. S.& Veloso, Rosângela R.& Reis, Tatiana C.& Gomes, Crizian S.& Neto, João F. R.…[et al.]. 2014. Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension : A Preliminary Population-Based Cross-Sectional Study. Cardiology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pena, Geórgia das Graças…[et al.]. Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension : A Preliminary Population-Based Cross-Sectional Study. Cardiology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-505607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pena, Geórgia das Graças& Guimarães, Andre L. S.& Veloso, Rosângela R.& Reis, Tatiana C.& Gomes, Crizian S.& Neto, João F. R.…[et al.]. Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension : A Preliminary Population-Based Cross-Sectional Study. Cardiology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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