The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line TB Drugs Reveals Stress- and PEPPE-Related Drug Targets
المؤلفون المشاركون
المصدر
International Journal of Microbiology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-07-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
الملخص EN
Tuberculosis is a leading infectious disease causing millions of deaths each year.
How to eradicate mycobacterial persistence has become a central research focus for developing next-generation TB drugs.
Yet, the knowledge in this area is fundamentally limited and only a few drugs, notably capreomycin and PA-824, have been shown to be active against non-replicating persistent TB bacilli.
In this study, we performed a new bioinformatics analysis on microarray-based gene expression data obtained from the public domain to explore genes that were differentially induced by drugs between the group of capreomycin and PA-824 and the group of mainly the first-line TB drugs.
Our study has identified 42 genes specifically induced by capreomycin and PA-824.
Many of these genes are related to stress responses.
In terms of the distribution of identified genes in a specific category relative to the whole genome, only the categories of PE/PPE and conserved hypotheticals have statistical significance.
Six among the 42 genes identified in this study are on the list of the top 100 persistence targets selected by the TB Structural Genomics Consortium.
Further biological elucidation of their roles in mycobacterial persistence is warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Li M.& Tai, Shu C.. 2009. The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line TB Drugs Reveals Stress- and PEPPE-Related Drug Targets. International Journal of Microbiology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-505660
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Li M.& Tai, Shu C.. The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line TB Drugs Reveals Stress- and PEPPE-Related Drug Targets. International Journal of Microbiology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-505660
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Li M.& Tai, Shu C.. The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line TB Drugs Reveals Stress- and PEPPE-Related Drug Targets. International Journal of Microbiology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-505660
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505660
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر