Monoclonal Antibodies in Gynecological Cancer : A Critical Point of View
المؤلفون المشاركون
Zizzari, Ilaria Grazia
Bellati, Filippo
Ruscito, Ilary
Caccetta, Jlenia
Visconti, Valeria
Napoletano, Chiara
Gasparri, Maria Luisa
Rughetti, Aurelia
Benedetti-Panici, Pierluigi
Nuti, Marianna
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-26
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
During the last decades, several improvements in treating gynecological malignancies have been achieved.
In particular, target therapies, mostly monoclonal antibodies, have emerged as an attractive option for the treatment of these malignancies.
In fact, various molecular-targeted agents have been developed for a variety of malignancies with the objective to interfere with a precise tumor associated receptor, essential for cancer cell survival or proliferation, blocking its function, of the cancer cells.
Alternatively, monoclonal antibodies have been developed to block immune suppression or enhance functions of immune effector cells.
So far, several monoclonal antibodies have been tested for clinical efficacy for the treatment of gynecological cancers.
Antibodies against Vascular Endothelial Growth Factor (VEGF) and Epidermal Growth Factor Receptor (EGFR) have been used in different neoplasms such as ovarian and cervical cancer.
Catumazumab, a bivalent antibody against CD3 and EpCAM, is effective in the treatment of neoplastic ascites.
Other antibodies are peculiar for specific cancer-associated antigen such as Oregovomab against CA125 or Farletuzumab against the folate receptor.
Here we describe the preclinical and clinical experience gained up to now with monoclonal antibodies in tumors of the female genital tract and trace future therapeutic and research venues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bellati, Filippo& Napoletano, Chiara& Gasparri, Maria Luisa& Visconti, Valeria& Zizzari, Ilaria Grazia& Ruscito, Ilary…[et al.]. 2011. Monoclonal Antibodies in Gynecological Cancer : A Critical Point of View. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-505761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bellati, Filippo…[et al.]. Monoclonal Antibodies in Gynecological Cancer : A Critical Point of View. Clinical and Developmental Immunology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-505761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bellati, Filippo& Napoletano, Chiara& Gasparri, Maria Luisa& Visconti, Valeria& Zizzari, Ilaria Grazia& Ruscito, Ilary…[et al.]. Monoclonal Antibodies in Gynecological Cancer : A Critical Point of View. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-505761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر