![](/images/graphics-bg.png)
Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury
المؤلفون المشاركون
Eaton, Mary J.
Wolfe, Stacey Quintero
Widerström-Noga, Eva
المصدر
Neurology Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-01
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Transplant of cells which make biologic agents that can modulate the sensory and motor responses after spinal cord injury (SCI) would be useful to treat pain and paralysis.
To address this need for clinically useful human cells, a unique neuronal cell line that synthesizes and secretes/releases the neurotransmitter serotonin (5HT) was isolated.
Hind paw tactile allodynia and thermal hyperalgesia induced by severe contusive SCI were potently reversed after lumbar subarachnoid transplant of differentiated cells, but had no effect on open field motor scores, stride length, foot rotation, base of support, or gridwalk footfall errors associated with the SCI.
The sensory effects appeared 1 week after transplant and did not diminish during the 8-week course of the experiment when grafts were placed 2 weeks after SCI.
Many grafted cells were still present and synthesizing 5HT at the end of the study.
These data suggest that the human neuronal serotonergic hNT2.19 cells can be used as a biologic minipump for receiving SCI-related neuropathic pain, but likely requires intraspinal grafts for motor recovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eaton, Mary J.& Widerström-Noga, Eva& Wolfe, Stacey Quintero. 2011. Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury. Neurology Research International،Vol. 2011, no. 2011, pp.1-24.
https://search.emarefa.net/detail/BIM-505855
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eaton, Mary J.…[et al.]. Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury. Neurology Research International No. 2011 (2011), pp.1-24.
https://search.emarefa.net/detail/BIM-505855
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eaton, Mary J.& Widerström-Noga, Eva& Wolfe, Stacey Quintero. Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-24.
https://search.emarefa.net/detail/BIM-505855
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505855
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)